Connect with us

Hi, what are you looking for?

News

Researchers Find Synthetic CBD Effective in Treating Seizures in Rats

Is there a future in synthetic CBD?

Researchers Find Synthetic CBD Effective in Treating Seizures in Rats
Tsyb Oleh/ Shutterstock

Researchers at the University of California Davis have determined that a synthetic analog to cannabidiol can be effective for treating seizures in lab rats. Results of the research led by Mark Mascal, a professor in the UC Davis Department of Chemistry in collaboration with the University of Reading, U.K., were published last week by the journal Scientific Reports.

Researchers compared the effectiveness of herbal CBD and a synthetic version of CBD known as 8,9-Dihydrocannabidiol (H2CBD) in treating induced seizures in lab rats. They determined that the two compounds were equally effective in reducing both the frequency and severity of seizures.

Mascal said in a university press release that his lab has developed a process to produce H2CBD easily and inexpensively using commercially available chemicals. The manmade version of the drug has several advantages over its naturally derived counterpart, according to Mascal.

“It’s a much safer drug than CBD, with no abuse potential and doesn’t require the cultivation of hemp,” he said.

Hemp cultivation for CBD takes up land that could be used for other agricultural uses, including the cultivation of other varieties of hemp that can be used to produce fiber, grain, or oilseed. H2CBD can be produced more economically with greater purity than hemp-derived CBD plant extracts. Also, the synthetic analog can’t be chemically altered to produce psychoactive cannabinoids.

“Unlike CBD, there is no way to convert H2CBD to intoxicating THC,” Mascal said. 

More Research Planned

Mascal and his colleagues at the UC Davis School of Medicine are continuing their research with animals and hope to begin clinical trials of H2CBD soon. UC Davis has applied for a patent for the anti-seizure applications of the compound and Mascal has founded a company, Syncanica, to further develop the synthetic cannabinoid.

CBD has been shown to be an effective treatment for seizure disorders in humans. It is the active ingredient of Epidiolex, the first medication derived directly from cannabis to be approved by the U.S. Food and Drug Administration. Epidiolex was approved to treat seizures caused by two rare forms of epilepsy, but the high cost of the drug, up to $30,000 per patient per year, leaves the medication out of reach for many patients not covered by insurance.

The approval of Epidiolex led to the rescheduling of the medication under the Controlled Substances Act by the DEA in September 2018, although the agency did not reschedule cannabis or CBD. The medication became available by prescription only in November.

Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Advertisement

HT Newsletter

Subscribe for exclusive access to deals, free giveaways and more!

Thank you for subscribing.

Something went wrong.

Advertisement

You May Also Like

News

The California Bureau of Cannabis Control is continuing to crack down on the illicit market.

News

Rapper and dispensary owner Berner made a statement about the events on his Instagram page.

News

Because of the restrictions necessary in the time of COVID-19, many are looking for new ways to consume cannabis—including drinking it.

News

In the interest of harm reduction San Francisco, healthcare workers are administering limited amounts of certain substances to people experiencing homelessness and addiction.

News

Complaints about illegal pot growing led to a large-scale bust on the Round Valley Indian Reservation.

News

A police officer in Rancho Cordova, California was caught on camera punching a child suspected of illicit marijuana use.

Business

Hightimes Holding announced a deal with Harvest Health & Recreation.

News

Santa Clara County is making significant strides towards criminal justice reform.

Do NOT follow this link or you will be banned from the site!